Carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes
responsible for the hydrolysis of various clinical drugs. Our recent study demonstrated that …

Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …

Mammalian carboxylesterase 1 enzymes can hydrolyze many xenobiotic chemicals and
endogenous lipids. We here identified and characterized a mouse strain (FVB/NKI) in which …

Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in
hydrolytic biotransformation of numerous medications. Considerable interindividual …

Carboxylesterase 1 (CE1) is an important serine hydrolase in mammals, which involved in
the hydrolysis of a variety of compounds (endogenous substrates like cholesterol and …

Carboxylesterases (CE) are ubiquitous enzymes thought to be responsible for the
metabolism and detoxification of xenobiotics. Numerous clinically used drugs including …

Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …

In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …

Carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and
exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid …