The nonclassical major histocompatibility complex of class II molecules (ncMHCII) HLA‐DM
(DM) and HLA‐DO (DO) feature essential functions for the selection of the peptides that are …

Classical human leukocyte antigen (HLA) molecules of the major histocompatibility class II
(MHCII) complex present peptides for the development, surveillance and activation of CD4+ …

Presentation of antigenic peptides on MHC-II molecules is essential for tolerance to self and
for initiation of immune responses against foreign antigens. DO (HLA-DO in humans, H2-O …

HLA-DM serves a critical function in the loading and editing of peptides on MHC class II
(MHCII) molecules. Recent data showed that the interaction cycle between MHCII molecules …

In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …

Antigen processing and loading of peptides onto MHC class II molecules is a multistep
process that involves vesicular transport of the MHCII molecules along the secretory …

Peptides presented by major histocompatibility complex class II (MHCII) molecules to CD4+
T cells play a central role in the initiation of adaptive immunity. This antigen presentation …

Considerable progress has been made in the field of major histocompatibility complex
(MHC) class II-restricted antigen presentation. The analysis of mutant cell lines defective in …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

In B cells, the non‐classical human leukocyte antigens HLA‐DO (DO) and HLA‐DM (DM)
are residents of lysosome‐like organelles where they form tight complexes. DM catalyzes …