Desai AN, Jere A. Next‐generation sequencing: ready for the clinics? Next‐generation
sequencing (NGS) has transformed genomic research by decreasing the cost of sequencing …

Fifteen years after the completion of first human genome sequencing, the technique is
almost a commodity but there is still little evidence of its usefulness as a diagnostic …

Advances and declining costs in sequencing technology will result in increasing number of
studies with individual sequence data linked to phenotypic information, which has been …

Objectives Genome sequencing is poised to be incorporated into clinical care for diagnoses
of rare diseases and some cancers in many parts of the world. Healthcare professionals are …

Historically, sequencing has been the key technology to assess variation in the genetic
code, and has been widely accepted in clinical diagnostics of genetic disease. The advent of …

Recent technological advances have radically changed genetic testing from an expensive
and burdensome undertaking to a rapid and less costly option for many purposes. The utility …

During the last 25 years, a small number of meaningful DNA-based diagnostic tests have
been available to aid in the diagnosis and subsequent treatment of heritable disorders …

© 2013 BioMed Central Ltd accompanying the emergence of population genomic
sequencing technologies. This is especially true in light of genomic science's rapid …

Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic
diagnosis of rare and unknown diseases and for identification of actionable cancer drivers …

Implementation of next-generation DNA sequencing (NGS) technology into routine
diagnostic genome care requires strategic choices. Instead of theoretical discussions on the …