Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …
[HTML][HTML] Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer's disease
P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …
[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction
C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …
Role of p38/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy
A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …
[HTML][HTML] A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an …
L Munoz, HR Ranaivo, SM Roy, W Hu, JM Craft… - Journal of …, 2007 - Springer
Background An accumulating body of evidence is consistent with the hypothesis that
excessive or prolonged increases in proinflammatory cytokine production by activated glia is …
excessive or prolonged increases in proinflammatory cytokine production by activated glia is …
[HTML][HTML] A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …
p38 MAP kinase inhibitors as potential therapeutic drugs for neural diseases
S Yasuda, H Sugiura, H Tanaka… - … System Agents in …, 2011 - ingentaconnect.com
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by various cellular
stresses, as well as in response to inflammatory cytokines. In the central nervous systems …
stresses, as well as in response to inflammatory cytokines. In the central nervous systems …
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease
SAL Corrêa, KL Eales - Journal of signal transduction, 2012 - Wiley Online Library
A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …
[HTML][HTML] Selective brain-targeted antagonism of p38 MAPKα reduces hippocampal IL-1β levels and improves morris water maze performance in aged rats
JJ Alam - Journal of Alzheimer's Disease, 2015 - content.iospress.com
Background: P38 mitogen activated protein kinase (MAPK) α modulates microglia-mediated
inflammatory responses and a number of neuronal physiological processes. Objective: To …
inflammatory responses and a number of neuronal physiological processes. Objective: To …
The p38 MAP kinase signaling pathway in Alzheimer's disease
GVW Johnson, CDC Bailey - Experimental neurology, 2003 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. AD is
characterized by progressive neuronal degeneration that is accompanied by the formation of …
characterized by progressive neuronal degeneration that is accompanied by the formation of …