L‐Ala‐substituted rat galanin analogs distinguish between hypothalamic and jejunal galanin receptor subtypes
A JURÉUS, ÜLO LANGEL… - The Journal of peptide …, 1997 - Wiley Online Library
In order to explore which amino acids or which blocks of amino acids in the 29 amino acid
neuropeptide galanin are important for recognition of the endogenous ligand by galanin …
neuropeptide galanin are important for recognition of the endogenous ligand by galanin …
Linear and cyclic N‐terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor
TUT Land, OLO Langel, M LÖW… - … journal of peptide …, 1991 - Wiley Online Library
The neuropeptide galanin (1–29) binds with high affinity to hypothalamic receptors (KD∼
0.9 nM) and regulates feeding behavior. The N‐terminal fragments (1–16),(1–16) NH2 are …
0.9 nM) and regulates feeding behavior. The N‐terminal fragments (1–16),(1–16) NH2 are …
Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 …
D Wynick, DM Smith, M Ghatei… - Proceedings of the …, 1993 - National Acad Sciences
Structure-activity studies demonstrate that galanin fragments 1-15 and 2-29 are fully active,
whereas fragment 3-29 has been reported to be inactive, in a number of different in vivo …
whereas fragment 3-29 has been reported to be inactive, in a number of different in vivo …
Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists
R Lang, A Berger, R Santic, R Geisberger, A Hermann… - Neuropeptides, 2005 - Elsevier
The hypothalamic galanin-like peptide (GALP) was isolated by its ability to activate galanin
receptors. The mature porcine GALP is a 60-amino acid neuropeptide proteolytically …
receptors. The mature porcine GALP is a 60-amino acid neuropeptide proteolytically …
[HTML][HTML] Short N-terminal galanin fragments are occurring naturally in vivo
R Ihnatko, E Theodorsson - Neuropeptides, 2017 - Elsevier
The galanin family currently consists of four peptides, namely galanin, galanin-message
associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through …
associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through …
Molecular cloning and pharmacological characterization of a new galanin receptor subtype
S Wang, T Hashemi, C He, C Strader, M Bayne - Molecular Pharmacology, 1997 - ASPET
Galanin, a 29–30-amino acid neuropeptide, is widely distributed in central and peripheral
systems and mediates a variety of physiological functions. Pharmacological studies have …
systems and mediates a variety of physiological functions. Pharmacological studies have …
Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus
JN Crawley, MC Austin, SM Fiske, B Martin… - Journal of …, 1990 - Soc Neuroscience
Synthetic fragments of galanin 1–29 were administered intraventricularly or into the
paraventricular nucleus of the hypothalamus for analysis of the critical amino acid sequence …
paraventricular nucleus of the hypothalamus for analysis of the critical amino acid sequence …
Galanin receptors in human basal forebrain differ from receptors in the hypothalamus: characterization using [125I] galanin (porcine) and [125I] galantide.
DC Deecher, OO Odusan, EJ Mufson - Journal of Pharmacology and …, 1995 - ASPET
Galanin, a 29-amino acid peptide, is uniquely distributed in human basal forebrain and may
play a role in cholinergic cell dysfunction in Alzheimer's disease. We report a detailed …
play a role in cholinergic cell dysfunction in Alzheimer's disease. We report a detailed …
Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides
LW Fitzgerald, JP Patterson, DS Conklin… - … of Pharmacology and …, 1998 - ASPET
The galanin neuropeptide system is widely distributed throughout the brain and periphery
and is thought to play a role in feeding, pain and reproduction. To evaluate the human …
and is thought to play a role in feeding, pain and reproduction. To evaluate the human …
Galanin receptors in human hypothalamus: biochemical and structural analysis
AM Lorinet, F Javoy-Agid, M Laburthe… - European Journal of …, 1994 - Elsevier
Galanin receptors have been characterized in normal human hypothalamus using 125 I-
galanin binding assays. Competition experiments of porcine 125 I-galanin binding to human …
galanin binding assays. Competition experiments of porcine 125 I-galanin binding to human …