Robust and cost-effective genome editing in a diverse array of cells and model organisms is
now possible thanks to the discovery of the RNA-guided endonucleases of the CRISPR-Cas …

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …

Clustered regularly interspaced short palindromic repeats (CRISPR), and associated
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …

CRISPR-Cas systems defend prokaryotes against bacteriophages and mobile genetic
elements and serve as the basis for revolutionary tools for genetic engineering. Class 2 …

The Cas9 endonuclease is the central component of the Type II CRISPR/Cas system, a
prokaryotic adaptive restriction system against invading nucleic acids, such as those …

Targeted genome editing using engineered nucleases has rapidly gone from being a niche
technology to a mainstream method used by many biological researchers. This widespread …

The C lustered R egions of I nterspersed P alindromic R epeats-Cas9 (CRISPR/Cas9), a
viral defense system found in bacteria and archaea, has emerged as a tour de force genome …

The discovery and subsequent repurposing of the CRISPR (clustered regularly interspaced
short palindromic repeats) and Cas proteins (CRISPR-associated proteins) has …

The RNA-guided CRISPR-associated (Cas) nucleases are versatile tools for genome editing
in various organisms. The large sizes of the commonly used Cas9 and Cas12a nucleases …

Cas9, the RNA-guided DNA endonuclease from the CRISPR-Cas (clustered regularly
interspaced short palindromic repeat–CRISPR-associated) system, has been adapted for …