Untargeted metabolomics (including lipidomics) is a holistic approach to biomarker
discovery and mechanistic insights into disease onset and progression, and response to …

RATIONALE Data analysis is a key step in mass spectrometry based untargeted
metabolomics, starting with the generation of generic peak lists from raw liquid …

To address the challenges associated with metabolomics analyses, such as identification of
chemical structures and elimination of experimental artifacts, we developed a platform that …

Metabolomics has emerged in the past decade as a highly attractive and impactful
technique for phenotype-level profiling in diverse biological applications. Most recently, the …

Mass spectrometry-based metabolomics is the comprehensive study of naturally occurring
small molecules collectively known as the metabolome. Given the vast structural diversity …

Recently, interest in untargeted metabolomics has become prevalent in the general scientific
community among an increasing number of investigators. The majority of these …

Highlights•Chromatography-based mass spectrometry (MS) allows profiling 100 samples
per day.•Thousands of samples per day can be efficiently analyzed by omitting …

In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …

Hydrophilic interaction chromatography (HILIC) is an emerging separation mode of liquid
chromatography (LC). Using highly hydrophilic stationary phases capable of retaining …

A key step in metabolomics is to perform accurate relative quantification of the metabolomes
in comparative samples with high coverage. Hydroxyl-containing metabolites are an …