Cytotoxic immunity in peripheral nerve injury and pain
Cytotoxicity and consequent cell death pathways are a critical component of the immune
response to infection, disease or injury. While numerous examples of inflammation causing …
response to infection, disease or injury. While numerous examples of inflammation causing …
Targeting the microglial signaling pathways: new insights in the modulation of neuropathic pain
K Popiolek-Barczyk, J Mika - Current Medicinal Chemistry, 2016 - ingentaconnect.com
The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …
are now recognized to play essential roles in many pathologies. Many studies within the last …
The role of glia and the immune system in the development and maintenance of neuropathic pain
Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …
pathophysiologic mechanisms and origins. Recent studies indicate a communication …
Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain
P Sacerdote, S Franchi, S Moretti, M Castelli… - Journal of neuroimmune …, 2013 - Springer
Neuropathic pain originates from a damage or disease affecting the somatosensory system.
Its treatment is unsatisfactory as it appears refractory to most analgesics. Animal models of …
Its treatment is unsatisfactory as it appears refractory to most analgesics. Animal models of …
Neuropathic pain and cytokines: current perspectives
AK Clark, EA Old, M Malcangio - Journal of pain research, 2013 - Taylor & Francis
Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …
debilitating suffering and is largely resistant to currently available analgesics. A …
Immune actions on the peripheral nervous system in pain
JA Liu, J Yu, CW Cheung - International journal of molecular sciences, 2021 - mdpi.com
Pain can be induced by tissue injuries, diseases and infections. The interactions between
the peripheral nervous system (PNS) and immune system are primary actions in pain …
the peripheral nervous system (PNS) and immune system are primary actions in pain …
Pathological and protective roles of glia in chronic pain
ED Milligan, LR Watkins - Nature reviews neuroscience, 2009 - nature.com
Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …
activation, both astrocytes and microglia respond to and release a number of signalling …
[HTML][HTML] Central nervous system targets: glial cell mechanisms in chronic pain
CR Donnelly, AS Andriessen, G Chen, K Wang… - …, 2020 - Elsevier
Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
Role of the immune system in neuropathic pain
M Malcangio - Scandinavian journal of pain, 2019 - degruyter.com
Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …
however pain can outlast its protective purpose and persist beyond injury, becoming …