New therapeutic approaches to resolve persistent pain are highly needed. We tested the
hypothesis that manipulation of cytokine receptors on sensory neurons by clustering …

Chronic pain is a debilitating condition that often emerges as a clinical symptom of
inflammatory diseases. It has therefore been widely accepted that the immune system …

The cytokine cascade in pain and inflammatory processes is a tremendously complex
system, involving glial, immune, and neuronal cell interactions. IL-1β is a pro-inflammatory …

Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …

Chronic pain is a disabling disease with limited treatment options. While animal models
have revealed important aspects of pain neurobiology, therapeutic translation of this …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …

Damage to the peripheral nervous system often leads to chronic neuropathic pain
characterized by spontaneous pain and an exaggerated response to painful and/or …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Despite being the mainstay of pain management, opioids are limited in their clinical utility by
adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 …

Nociceptors and immune cells both protect the host from potential threats to homeostasis.
There is growing evidence for bidirectional signalling between these two systems, and the …