In humans, obesity is associated with brain inflammation, glial reactivity, and immune cells
infiltration. Studies in rodents have shown that glial reactivity occurs within 24 hr of high‐fat …

Glial cells can mediate hypothalamic inflammatory processes induced in response to a high-
fat diet (HFD). We used magnetic-activated cell sorting (MACS) to isolate microglia and …

Diets rich in saturated fat produce inflammation, gliosis, and neuronal stress in the
mediobasal hypothalamus (MBH). Here, we show that microglia mediate this process and its …

Background Hypothalamic inflammation including astrogliosis and microglia activation
occurs after intake of high fat diet (HFD) in rodent models or in obese individuals. However …

Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …

Objective The hypothalamus of hypercaloric diet-induced obese animals is featured by a
significant increase of microglial reactivity and its associated cytokine production. However …

Diet‐induced obesity (DIO) is associated with chronic, low‐grade inflammation in the
hypothalamus, a key regulator of energy homeostasis. Current studies have revealed the …

Diets high in fat (HFD) are known to cause an immune response in the periphery as well as
the central nervous system. In peripheral adipose tissue, this immune response is primarily …

Abstract Background/Objectives High-fat diet consumption is known to trigger an
inflammatory response in the hypothalamus, which has been characterized by an initial …

Background Exposure of rodents to chronic high-fat diet (HFD) results in upregulation of
inflammatory markers and proliferation of microglia within the mediobasal hypothalamus …