Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes
AR Moran, Y Norimatsu, DC Dawson… - American Journal of …, 2014 - journals.physiology.org
The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel inhabits
the apical membrane of airway epithelia, where its function is essential for mucus hydration …
the apical membrane of airway epithelia, where its function is essential for mucus hydration …
The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance …
Acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction may
contribute to chronic obstructive pulmonary disease pathogenesis and is a potential …
contribute to chronic obstructive pulmonary disease pathogenesis and is a potential …
Cigarette smoke regulates the expression of the CFTR chloride channel in bronchial epithelial cells
F Hassan, J Rennolds, G Nuovo, ME Ezzie… - … IN HEALTH AND …, 2011 - atsjournals.org
The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel
that resides in the apical membrane of airway epithelial cells. Decreased CFTR expression …
that resides in the apical membrane of airway epithelial cells. Decreased CFTR expression …
Evaluation of secondhand smoke effects on CFTR function in vivo
LW Rasmussen, D Stanford, K Patel, SV Raju - Respiratory Research, 2020 - Springer
Background Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion
channel expressed on the mucosal surface of epithelial cells lining several tissues including …
channel expressed on the mucosal surface of epithelial cells lining several tissues including …
Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway …
AC Tanjala, JX Jiang, PDW Eckford… - Respiratory …, 2024 - Springer
Abstract Background Cystic Fibrosis causing mutations in the gene CFTR, reduce the activity
of the CFTR channel protein, and leads to mucus aggregation, airway obstruction and poor …
of the CFTR channel protein, and leads to mucus aggregation, airway obstruction and poor …
Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function
SV Raju, PL Jackson, CA Courville… - American journal of …, 2013 - atsjournals.org
Rationale: Several extrapulmonary disorders have been linked to cigarette smoking.
Smoking is reported to cause cystic fibrosis transmembrane conductance regulator (CFTR) …
Smoking is reported to cause cystic fibrosis transmembrane conductance regulator (CFTR) …
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers
AM Cantin, JW Hanrahan, G Bilodeau… - American journal of …, 2006 - atsjournals.org
Rationale: Cigarette smoke extract inhibits chloride secretion in human bronchial epithelial
cells. Oxidants decrease gene expression, protein expression, and function of the cystic …
cells. Oxidants decrease gene expression, protein expression, and function of the cystic …
Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia
Genetic and acquired loss-of-function defect of the cystic fibrosis transmembrane
conductance regulator (CFTR) compromise airway surface liquid homeostasis and …
conductance regulator (CFTR) compromise airway surface liquid homeostasis and …
Cigarette smoke and calcium conspire to impair CFTR function in airway epithelia
AP Braun - Channels, 2014 - Taylor & Francis
To maintain health and function in response to inhaled environmental irritants and toxins,
the lungs and airways depend upon an innate defense system that involves the secretion of …
the lungs and airways depend upon an innate defense system that involves the secretion of …
Exposure to cigarette smoke condensate reduces calcium activated chloride channel transport in primary sinonasal epithelial cultures
FW Virgin, C Azbell, D Schuster, J Sunde… - The …, 2010 - Wiley Online Library
Abstract Objectives/Hypothesis: The cystic fibrosis transmembrane conductance regulator
(CFTR) serves as a predominant Cl− transport conduit in airway epithelium and is inhibited …
(CFTR) serves as a predominant Cl− transport conduit in airway epithelium and is inhibited …