The effects of aging on the immune system are manifest at multiple levels that include
reduced production of B and T cells in bone marrow and thymus and diminished function of …

Immunosenescence influences many components of the immune system. Most importantly,
profound changes in T cell function are evident in older individuals. The impact of aging on …

Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-
cellular milieu and together these processes ensure that a population of naive CD4 T cells …

Rheumatoid arthritis (RA), like many other autoimmune syndromes, is a disease of adults,
with the highest incidence rates reported in the elderly. The immune system undergoes …

Constant exposure to new and persisting antigens and the need to replace cellular attrition
with newly built cells lead to profound remodeling of the immune system after the age of 50 …

T cell responses are altered in the aged in a manner usually interpreted as detrimental to
host defences against infectious agents and possibly also against cancer. T cell …

Aging is associated with a dysregulation of the immune response, loosely termed
“immunosenescence.” Each part of the immune system is influenced to some extent by the …

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Changes in the T-lymphocyte compartment represent the most critical component of
immunological aging. Recent studies have demonstrated that the age-related decline in T …

Immunosenescence, the progressive decline in immune function that develops with age,
results from cumulative alterations in critical B-and T-cell subpopulations. Decreases in …