The genesis for this Special Issue devoted to “3D Imaging in Lung Biology” emerged when
the two of us met for the first time as faculty at the Jackson Laboratory's course,“Phenotyping …

Stereology is the method of choice for the quantitative assessment of biological objects in
microscopy. It takes into account the fact that, in traditional microscopy such as conventional …

The delicate structure of murine lungs poses many challenges for acquiring high-quality
images that truly represent the living lung. Here, we describe several optimized procedures …

Rudolf Virchow, the founder of cellular pathology, held that even when physical or chemical
investigations yield the laws of physiology or medicine, the anatomist can still proudly state …

Since its entry into biomedical research in the first half of the twentieth century, electron
microscopy has been a valuable tool for lung researchers to explore the lung's delicate …

Respiratory diseases are a major reason for death in both men and women worldwide. The
development of therapies for these diseases has been slow and the lack of relevant human …

Most medical imaging is inherently three-dimensional (3D) but for validation of pathological
findings, histopathology is commonly used and typically histopathology images are acquired …

3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current
state of art 3D lung models and novel techniques that can be used to regenerate lung tissue …

Abstract 3D imaging is becoming more and more popular, as it allows us to identify
interactions between structures in organs. Furthermore, it gives the possibility to quantify and …

Investigating the structure and function of pulmonary alveoli in vivo is crucial for
understanding the normal and diseased lung. In particular, understanding the three …