Immune checkpoint blockade (ICB)-based or natural cancer immune responses largely
eliminate tumours. Yet, they require additional mechanisms to arrest those cancer cells that …

Cancer control by adaptive immunity involves a number of defined death,,,,,,, and clearance,,
mechanisms. However, efficient inhibition of exponential cancer growth by T cells and …

In response to oncogenic threats, tumor suppressor mechanisms that halt cell‐cycle
progression can stimulate immune‐mediated destruction of pre‐malignant and malignant …

The potential of immune checkpoint inhibitors (ICI) may be limited in situations where
immune cell fitness is impaired. Here, we show that the efficacy of cancer immunotherapies …

Background: Tumor cell senescence is a common outcome of anticancer therapy. Here we
investigated how therapy-induced senescence (TIS) affects tumor-infiltrating leukocytes …

Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that,
in some instances, stimulates the immune clearance of senescent cells. Using an immune …

Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading
to durable response rates. Important mechanisms of action of ICB therapy include …

Age is a major risk factor for solid cancers, hitherto conventionally viewed in the context of
the cell biology of carcinogenesis. However, if cancers are immunogenic, the immune …

Normal cells can respond to expression of activated oncogenes by initiating cellular
senescence, a permanent state of proliferative arrest. But whether this process reflects a …

Reciprocal interactions between tumor cells and immune cells shape the tumor
microenvironment. Recent studies indicate that enhanced cell cycle activity in cancer cells …