Neural stem/progenitor cell‐laden microfibers promote transplant survival in a mouse transected spinal cord injury model

K Sugai, S Nishimura, M Kato‐Negishi… - Journal of …, 2015 - Wiley Online Library
Previous studies have demonstrated that transplantation of neural stem/progenitor cells
(NS/PCs) into the lesioned spinal cord can promote functional recovery following incomplete …

Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection

M Aizawa-Kohama, T Endo, M Kitada… - Cell …, 2013 - journals.sagepub.com
After severe spinal cord injury, spontaneous functional recovery is limited. Numerous studies
have demonstrated cell transplantation as a reliable therapeutic approach. However, it …

Fate of transplanted adult neural stem/progenitor cells and bone marrow–derived mesenchymal stromal cells in the injured adult rat spinal cord and impact on …

AM Parr, I Kulbatski, XH Wang, A Keating, CH Tator - Surgical neurology, 2008 - Elsevier
Background Neural stem/progenitor cells derived from the ependymal region of the spinal
cord may have the ability to regenerate the injured mammalian spinal cord as they do in …

The effects of the combination of mesenchymal stromal cells and nanofiber-hydrogel composite on repair of the contused spinal cord

AE Haggerty, I Maldonado-Lasunción, Y Nitobe… - Cells, 2022 - mdpi.com
A bone marrow-derived mesenchymal stromal cell (MSC) transplant and a bioengineered
nanofiber-hydrogel composite (NHC) have been shown to stimulate nervous tissue repair in …

Roles of mesenchymal stem cells in spinal cord injury

J Qu, H Zhang - Stem cells international, 2017 - Wiley Online Library
Spinal cord injury (SCI) represents one of the most complicated and heterogeneous
pathological processes of central nervous system (CNS) impairments, which is still beyond …

Graft of the gelatin sponge scaffold containing genetically‐modified neural stem cells promotes cell differentiation, axon regeneration, and functional recovery in rat …

BL Du, X Zeng, YH Ma, BQ Lai… - … Research Part A, 2015 - Wiley Online Library
Biological materials combined with genetically‐modified neural stem cells (NSCs) are
candidate therapy targeting spinal cord injury (SCI). Based on our previous studies, here we …

Transplantation of bone marrow mesenchymal stem cells reduces lesion volume and induces axonal regrowth of injured spinal cord

W Gu, F Zhang, Q Xue, Z Ma, P Lu, B Yu - Neuropathology, 2010 - Wiley Online Library
It has been demonstrated that transplantation of bone marrow mesenchymal stem cells
(BMSCs) improves recovery of injured spinal cord in animal models. However, the …

Co-transplantation of mesenchymal and neural stem cells and overexpressing stromal-derived factor-1 for treating spinal cord injury

AN Stewart, G Kendziorski, ZM Deak, DJ Brown… - Brain research, 2017 - Elsevier
Genetic engineering of mesenchymal stem cells (MSCs) and neuronal stem cells (NSCs)
has been used to treat spinal cord injuries (SCI). As a mechanism of therapy, MSCs secrete …

Combination of activated Schwann cells with bone mesenchymal stem cells: the best cell strategy for repair after spinal cord injury in rats

DX Ban, GZ Ning, SQ Feng, Y Wang… - Regenerative …, 2011 - Taylor & Francis
Aim: We aim to explore the repair effect of combined cell therapy using activated Schwann
cells (ASCs) and bone mesenchymal stem cells (BMSCs) in traumatic spinal cord injury …

Transplanted Neurally Modified Bone Marrow–Derived Mesenchymal Stem Cells Promote Tissue Protection and Locomotor Recovery in Spinal Cord Injured Rats

AR Alexanian, MG Fehlings, Z Zhang… - … and neural repair, 2011 - journals.sagepub.com
Background. Stem cell–based therapy for repair and replacement of lost neural cells is a
promising treatment for central nervous system (CNS) diseases. Bone marrow (BM)–derived …