We provide evidence that tumor cells can induce apoptosis of NK cells by engaging the
natural cytotoxicity receptors (NCR) NKp30, NKp44, and NKp46. Indeed, the binding …

Interaction of sensitive target cells with NK cells results in both positive and negative
signaling. Positive signaling results in the induction of NK cytotoxicity and sensitization for IL …

NK cells kill sensitive targets via exocytosis of cytoplasmic granules containing membrane
damaging perforins and DNA damaging granzymes. Therefore, the target cell can either die …

Osteosarcoma and Ewing's sarcoma tumor cells are susceptible to IL15-induced or antibody-
mediated cytolytic activity of NK cells in short-term cytotoxicity assays. When encountering …

Activated human natural killer (NK) cells undergo rapid apoptotic cell death after ligand
binding to the Fc receptor (CD16). We examined whether human NK cells die after …

Natural cytotoxicity receptors (NCRs) are major activating receptors involved in NK
cytotoxicity. NCR expression varies with the activation state of NK cells, and the expression …

Cytotoxic T lymphocytes and natural killer (NK) cells kill target cells by two main
mechanisms, namely, the perforin/granzymes and the Fas ligand (Fas-L) pathways. The …

Propriocidal regulation of T cells refers to apoptosis induced by interleukin‐2 (IL‐2)
activation with subsequent antigen receptor stimulation. We previously reported that natural …

ABSTRACT NK cells control tumor and virus-infected cells through releasing cytotoxic
granules and proinflammatory cytokines. IFN-γ and TNF-α secretions and cytotoxicity are …

Abstract The Fas/Fas-ligand (FasL) system seems to play a key role in regulating
immunoresponses. Highly purified CD56+ CD3− natural killer (NK) cells were found to be …