Abstract Interferon-γ (IFN-γ) is critical for an effective innate immune response against
infection. A combination of interleukins (ILs) derived from activated T cells (IL-2) and …

Abstract Interleukin‐2 (IL‐2)‐activated polyclonal or clonal NK cells lysed autologous
antigen presenting cells (APC) through the engagement of the natural cytotoxicity receptors …

NK cells provide a line of defense against tumors and virus-infected cells that have lost the
expression of one or more MHC class I isoforms. Here, we investigate whether inhibitors of …

We previously reported that natural killer (NK)-sensitive target cells, K562, kill interleukin-2-
stimulated (lymphokine-activated killer [LAK]) but not unstimulated NK cells. We have now …

AK-5 tumor cell death is mediated by natural killer cells through necrosis (perforin mediated)
and apoptosis. Apoptosis is the mechanism which operates in immune animalsin vivo. We …

Immune therapy of cancer is among the most promising recent advances in medicine.
Whether the immune system can keep cancer in check depends on, among other factors, the …

NK cell populations were derived from murine splenocytes stimulated by IL-2, IL-15, or the
combination of IL-12 and IL-18. Whereas NK cells derived with the latter cytokines consisted …

Natural killer cells mediate spontaneously secretory/necrotic killing against rare leukemia
cell lines and a nonsecretory/apoptotic killing against a large variety of tumor cell lines. The …

Natural killer (NK) cells can detect whether cells have undergone tumour transformation or
viral infection. The discovery of specific inhibitory receptors for major histocompatibility …

Triggering of cytotoxicity in human NK cells is induced by the combined engagement of
several triggering receptors. These include primary receptors such as NKG2D and the …