Interferon-α (IFN-α) was among the first cytokines studied and the earliest to be used in
clinical medicine for the treatment of viral infections and malignancies. Although the capacity …

Activation of natural killer (NK) cells with interleukin-2 (IL-2) and IL-12 leads to an enhanced
lysis of tumour cells. We investigated the ability of NK cells, with or without prior activation, to …

SR-91 is a natural killer (NK)-resistant leukemic cell line expressing a low level of ICAM-1.
Pre-treatment of SR-91 cells with TNF-α or IFN-γ, increased both ICAM-1 (CD54) expression …

Natural killer cells can discriminate between normal cells and cells that do not express
adequate amounts of major histocompatibility complex (MHC) class I molecules. The …

We examined the effect of exogenous IL-10 on the sensitivity of rat W14 and W31 tumor cells
to natural killer (NK) cell-mediated cytotoxicity in relation to previously identified NK target …

Background Investigating how the immune system functions during malignancies is crucial
to developing novel therapeutic strategies. Natural killer (NK) cells, an important component …

NK cells are a major component of innate immunity and exert a potent antitumor effect both
in vitro and in vivo. However, NK cells infiltrating solid tumors have been shown to display …

NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in
natural cytotoxicity. In this study we show that the surface density of NKp46 may vary in …

Propriocidal regulation of T cells refers to apoptosis induced by interleukin 2 (IL-2) activation
with subsequent antigen receptor stimulation. We examined whether natural killer (NK) cells …

The interaction of purified nonactivated human NK cells with target cells overnight results in
functional anergy and apoptosis in NK cells and in a change of the NK phenotype from …