NK cells have been shown to play an important role in the lungs with regards to tumor cell
clearance and resistance of this organ to metastases. Here, we have investigated whether …

Due to their physiological role in removing damaged cells, natural killer (NK) cells represent
ideal candidates for cellular immunotherapy in the treatment of cancer. Thereby, the …

NK recognition is regulated by a delicate balance between positive signals initiating their
effector functions, and inhibitory signals preventing them from proceeding to cytolysis …

NK cells are innate immune cells that are important in tumor immunity, but also have the
ability to modulate the adaptive immune system through cytokine production or direct cell …

NKG2D is a recently described activating receptor expressed by both NK cells and CTL. In
this study we investigated the role of NKG2D in the natural cytolysis mediated by NK cell …

NK cells are effectors in innate immunity and also participate in immunoregulation through
the release of TGF‐β1 and lysis of activated/autoreactive T cells. Apoptotic cells (AC) have …

Cells mediating natural killer (NK) activity mediate lysis against a variety of tumor cells and
may serve as important effector cells in host resistance to infection. NK active cells are …

Destruction of tumor cells is a key function of lymphocytes, but the molecular processes
driving it are unclear. Analysis of signal molecules indicated that mitogen-activated protein …

Compared with freshly isolated peripheral blood natural killer (NK) cells, the YT and NK-92
cell lines are characterized by elevated cytolytic activity. The molecular mechanisms …

Monokines IL12, IL15, and IL18 have been shown to activate NK cell function, however with
high apoptosis induced by their combination within 48h. Here, we demonstrate for the first …