Surface receptors involved in natural killer (NK) cell triggering during the process of tumor
cell lysis have recently been identified. Of these receptors, NKp44 is selectively expressed …

Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid
tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant …

The spontaneous regression of AK-5 histiocytoma is mediated by natural killer (NK) cells
through antibody-dependent cell-mediated cellular cytotoxicity (ADCC) and the target cell …

We examined the effect of IL-10 on sensitivity to NK-cell-mediated cytotoxicity of the H-ras-
induced transformants, W14 and W31. Incubation of cells with recombinant human (rh) IL-10 …

Natural killer cell stimulatory factor (NKSF) or interleukin‐12 (IL‐12) is a heterodimeric
cytokine with pleiomorphic effects on T and NK cells, including induction of lymphokine …

Innate and adaptive immunity cooperate to eliminate tumors. However, when infrequent
cancer cell variants are not destroyed, tumor growth and immunosurveillance enter into a …

After recognition, NK cells can kill susceptible target cells through perforin-dependent
mechanisms or by inducing death receptor-mediated apoptosis, and they can also secrete …

Historically, the name of natural killer (NK) cells came from their natural ability to kill tumor
cells in vitro. From the 1970s to date, accumulating data highlighted the importance of NK …

NK cells employ a variety of activating receptors to kill virally infected and tumor cells.
Prominent among these receptors are the natural cytotoxicity receptors (NCRs)(NKp30 …

MHC class I molecules protect normal and transformed cells from lysis by natural killer (NK)
cells through recognition of receptors expressed on leucocytes. Defects in NK cell activity …