Human NK cell recognition of target cells in the prism of natural cytotoxicity receptors and their ligands
M Brusilovsky, B Rosental, A Shemesh… - Journal of …, 2012 - Taylor & Francis
The matter of the pathogen-and cancer-associated ligands recognized by the Natural
Cytotoxicity Receptors (NCRs) has been a subject of intense research ever since the …
Cytotoxicity Receptors (NCRs) has been a subject of intense research ever since the …
The functional loss of human natural killer cell activity induced by K562 is reversible via an interleukin-2-dependent mechanism
SI Abrams, Z Brahmi - Cellular immunology, 1986 - Elsevier
In a recent study, we evaluated the functional status of human natural killer (NK) cells after
their interaction with the NK-sensitive tumor target cell (TC), K562. We demonstrated that …
their interaction with the NK-sensitive tumor target cell (TC), K562. We demonstrated that …
Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells
LS Metelitsa, OV Naidenko, A Kant, HW Wu… - The Journal of …, 2001 - journals.aai.org
Abstract α-Galactosylceramide (αGalCer) stimulates NKT cells and has antitumor activity in
mice. Murine NKT cells may directly kill tumor cells and induce NK cell cytotoxicity, but the …
mice. Murine NKT cells may directly kill tumor cells and induce NK cell cytotoxicity, but the …
A novel mechanism for cancer cells to evade immune attack by NK cells: the interaction between NKp44 and proliferating cell nuclear antigen
B Rosental, U Hadad, M Brusilovsky… - …, 2012 - Taylor & Francis
We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell
activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of …
activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of …
Mechanisms of apoptosis resistance to NK cell-mediated cytotoxicity in cancer
C Sordo-Bahamonde, S Lorenzo-Herrero… - International journal of …, 2020 - mdpi.com
Natural killer (NK) cells are major contributors to immunosurveillance and control of tumor
development by inducing apoptosis of malignant cells. Among the main mechanisms …
development by inducing apoptosis of malignant cells. Among the main mechanisms …
Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells
A Jewett, NA Cacalano, C Head, A Teruel - Clinical cancer research, 2006 - AACR
Down-modulation of CD16 (FcγRIII) receptors and loss of natural killer (NK) cell function
have been observed in oral cancer patients. However, neither the mechanisms nor the …
have been observed in oral cancer patients. However, neither the mechanisms nor the …
Cytotoxic potential of IL‐15‐activated cytokine‐induced killer cells against human neuroblastoma cells
C Cappel, S Huenecke, A Suemmerer… - Pediatric Blood & …, 2016 - Wiley Online Library
Background Neuroblastoma (NB) is the most common solid extracranial tumor in childhood.
Despite advances in therapy, the prognosis is poor and optimized therapies are urgently …
Despite advances in therapy, the prognosis is poor and optimized therapies are urgently …
Identification of human NK cells that are deficient for signaling adaptor FcRγ and specialized for antibody-dependent immune functions
I Hwang, T Zhang, JM Scott, AR Kim… - International …, 2012 - academic.oup.com
NK cells respond to tumor and virus-infected cells directly through several activation
receptors, including natural cytotoxicity receptors, or indirectly through the activating Fc …
receptors, including natural cytotoxicity receptors, or indirectly through the activating Fc …
IFN‐γ–STAT1‐mediated NK2R expression is involved in the induction of antitumor effector CD8+ T cells in vivo
W Shen, X Wang, H Xiang, S Shichi… - Cancer …, 2023 - Wiley Online Library
The induction of antitumor effector T cells in the tumor microenvironment is a crucial event
for cancer immunotherapy. Neurokinin receptor 2 (NK2R), a G protein‐coupled receptor for …
for cancer immunotherapy. Neurokinin receptor 2 (NK2R), a G protein‐coupled receptor for …
In vivo treatment with monoclonal antibody 3.2. 3 selectively eliminates natural killer cells in rats.
MR Van den Brink, LE Hunt, JC Hiserodt - The Journal of experimental …, 1990 - rupress.org
We recently described a mAb 3.2. 3 (IgG1), that recognizes a 60-kD dimeric molecule
expressed exclusively on fresh and rIL-2-activated NK cells and polymorphonuclear cells …
expressed exclusively on fresh and rIL-2-activated NK cells and polymorphonuclear cells …