Apigenin alleviated acetaminophen‐induced hepatotoxicity in low protein‐fed rats: targeting oxidative stress, STAT3, and apoptosis signals
WR Mohamed, AS Kotb… - … of biochemical and …, 2020 - Wiley Online Library
Apigenin (API) is a natural flavonoid abundant in fruits and vegetables. The present study
was undertaken to evaluate the effect of protein malnutrition (PMN) on acetaminophen …
was undertaken to evaluate the effect of protein malnutrition (PMN) on acetaminophen …
[HTML][HTML] Upregulation of Nrf2/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against …
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …
[PDF][PDF] Upregulation of Nrf2/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against …
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …
(CP). This study investigated the protective role of the flavone apigenin (API) against CP …
[HTML][HTML] Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway
L Zhao, J Zhang, C Hu, T Wang, J Lu, C Wu… - Frontiers in …, 2020 - frontiersin.org
Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …
Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice
Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via …
J Wan, G Kuang, L Zhang, R Jiang, Y Chen… - International …, 2020 - Elsevier
Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …
[HTML][HTML] Apigenin attenuates acetaminophen-induced hepatotoxicity by activating AMP-activated protein kinase/carnitine palmitoyltransferase I pathway
J Zhang, X Liang, J Li, H Yin, F Liu, C Hu… - Frontiers in …, 2020 - frontiersin.org
Overuse of acetaminophen (APAP) is a major cause of drug-induced liver failure at the
clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla. The aim of …
clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla. The aim of …
Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice
J Qi, Z Zhou, CW Lim, JW Kim, B Kim - Toxicology and Applied …, 2019 - Elsevier
Amlexanox, a clinically approved small-molecule therapeutic presently used to treat allergic
rhinitis, ulcer, and asthma, is an inhibitor of the noncanonical IkB kinase-ε (IKKε) and TANK …
rhinitis, ulcer, and asthma, is an inhibitor of the noncanonical IkB kinase-ε (IKKε) and TANK …
[PDF][PDF] Protective mechanisms of piperine against acetaminophen-induced hepatotoxicity may be mediated through TGFBRAP1.
OBJECTIVE: To investigate the possible protective mechanisms of piperine against
acetaminophen (APAP)-induced hepatotoxicity in mice. MATERIALS AND METHODS: Mice …
acetaminophen (APAP)-induced hepatotoxicity in mice. MATERIALS AND METHODS: Mice …
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
Isorhamnetin is a hepatoprotective flavonoid molecule derived from the leaves and fruits of
Hippophae rhamnoides L. However, the protective effect of isorhamnetin on acetaminophen …
Hippophae rhamnoides L. However, the protective effect of isorhamnetin on acetaminophen …