The move toward precision medicine has highlighted the importance of understanding
biological variability within and across individuals in the human population. In particular …

A major goal of systems biology is the development of models that accurately predict
responses to perturbation. Constructing such models requires the collection of dense …

Highlights•System-wide approaches are now applied to study vaccine response in healthy
adults.•Vaccine response involves multiple arms of immunity and can be predicted.•Robust …

Homo sapiens are genetically diverse, but dramatic demographic and socioeconomic
changes during the past century have created further diversification with respect to age …

The human immune system is a distributed system of specialized cell populations with
unique functions that collectively give rise to immune responses to infections and during …

The advent of high-throughput “omics” technologies, combined with the computational and
statistical methods necessary to analyze such data, have revolutionized biology, enabling a …

Immunotherapies, including vaccines, represent a potent tool to prevent or contain disease
with high morbidity or mortality such as infections and cancer. However, despite their …

Vaccines have drastically reduced the mortality and morbidity of many diseases. However,
vaccines have historically been developed empirically, and recent development of vaccines …

This is an exciting time for immunology because the future promises to be replete with
exciting new discoveries that can be translated to improve health and treat disease in novel …

Recent studies have demonstrated the utility of using systems approaches to identify
molecular signatures that can be used to predict vaccine immunity in humans. Such …