Background Germline mutations in the BRCA genes dramatically increase the risk of breast
cancer. In the general population, breast cancer risk is affected by age at menarche, by age …

Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for …

Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) and BRCA2
genes have a significant risk of developing breast and ovarian cancer over the course of …

Reports of BRCA genetic mutations and risk of death or recurrence are inconsistent. This
study aimed to compare overall and disease-free breast cancer survival rates between …

BRCA1/BRCA2 genes play a central role in DNA repair and their mutations increase
sensitivity to DNA-damaging agents. There are conflicting data regarding the prognostic …

Identifying breast cancer patients at increased risk for carrying a mutation in the BRCA1 and
BRCA2 genes is an important objective in clinical practice. Although age at diagnosis, family …

BRCA1 and BRCA2 germline mutations are associated with a strong risk of breast cancer,
which may preclude breast-conserving treatment in carriers. This study examined whether …

Germline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors
of breast and/or ovarian cancer development. The contribution of these mutations to breast …

We determined the prevalence and characteristics of BRCA1/2 germline mutations in a large
cohort of Chinese women with breast cancer. A total of 5931 unselected Chinese women …

A systematic review was conducted, summarizing international BRCA 1 or 2 (BRCA1/2)
mutation prevalence in breast cancer. Databases (eg, Medline and Embase; N= 7) and …