Hereditary breast cancer is known for its strong tendency of inheritance. Most hereditary
breast cancers are related to BRCA1/BRCA2 pathogenic variants. The lifelong risk of breast …

Women who carry a deleterious mutation in BRCA1 or BRCA2 have high lifetime risks of
breast and ovarian cancers. However, the influence of a family history of these cancers on …

Inherited mutations in the BRCA1 and BRCA2 genes are the strongest genetic predictors of
breast cancer and are the primary causes of familial breast/ovarian cancer syndrome. The …

Purpose Chemoprevention with a selective estrogen receptor modulator (tamoxifen or
raloxifene) is a non-surgical option offered to high-risk women to reduce the risk of breast …

Comparative effectiveness research has become an integral part of health care planning in
most developed countries. In a simulated cohort of women, aged 30–65, who tested positive …

Purpose Women with BRCA1/2 mutations inherit high risks of breast and ovarian cancer;
options to reduce cancer mortality include prophylactic surgery or breast screening, but their …

Introduction Most breast cancers that occur in women with germline BRCA1 mutations are
estrogen receptor-negative (ER-) and also typically lack expression of progesterone …

BACKGROUND. Women who are at increased risk for breast and ovarian cancers,
especially BRCA1 and BRCA2 mutation carriers, face a myriad of risk‐reduction options …

Background Advances in understanding molecular and genetic mechanisms underlying
cancer promise an “individualized” management of the disease. Women with a BRCA1 or …

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and
familial factors. About 50 common variants have been shown to modify BC risk for mutation …