Aldose Reductase (AR) is implicated in the development of secondary complications of
diabetes, providing an interesting target for therapeutic intervention. Extracts of Rauvolfia …

Abstract Background Plant-derived molecules (PDMs) are known to be a rich source of
diverse scaffolds that could serve as a basis for rational drug design. Structured compilation …

Hyperglycemia in diabetic patients results in a diverse range of complications such as
diabetic retinopathy, neuropathy, nephropathy and cardiovascular diseases. The role of …

In diabetes, increased accumulation of sorbitol has been associated with diabetic
complications through polyol pathway. Aldose reductase (AR) is one of the key factors …

Aldose reductase (ALR2), a vital enzyme involved in polyol pathway, has befitted as a novel
drug target in antidiabetes drug discovery process. In the present study, the binding mode …

The role of aldose reductase (ALR), the key enzyme of the polyol pathway, has been firmly
established in hyperglycemia-induced diabetic complications. Therefore, the present study …

Aldose reductase (ALR2) is a critical enzyme in the development of the major complications
of diabetes mellitus. Herein, new molecular entities active against ALR2 were discovered …

Diabetic peripheral neuropathy (DPN) is a common diabetes complication (DM). Aldose
reductase-2 (ALR-2) is an oxidoreductase enzyme that is most extensively studied …

Aldose reductase (ALR2) activation in the polyol pathway has been implicated as the
primary mechanism for the progression of diabetic retinopathy. Most of the aldose reductase …

Aldose reductase (AR), a cytosolic, monomeric oxidoreductase, is a key enzyme in the
polyol pathway which controls the conversion of glucose to sorbitol. The accumulation of …