Chronic heart failure continues to impose a substantial health-care burden, despite recent
treatment advances. The key pathophysiological process that ultimately leads to chronic …

The failing heart is characterized by complex tissue remodelling involving increased
cardiomyocyte death, and impairment of sarcomere function, metabolic activity, endothelial …

Heart failure is a leading cause of mortality in the United States. As a result of advances in
genetic technology, a molecular basis of heart failure is emerging. 1, 2 This review highlights …

Heart failure is a condition in which the heart cannot supply enough blood to the body's
organs, and is a final common consequence of various heart diseases. In the past 2 …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

Heart failure, or congestive heart failure, is a condition in which the heart cannot supply the
body's tissues with enough blood. The result is a cascade of changes that lead to severe …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …

Heart failure is a final common pathway in cardiovascular disease, as a result of sustained
pressure overload (ie, hypertension), myocardial ischemia or infarction, volume overload (ie …

Our understanding of the molecular processes which regulate cardiac function has grown
immeasurably in recent years. Even with the advent of β-blockers, angiotensin inhibitors and …