Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome

CC Chang, AA Dorasamy, BI Gosnell, JH Elliott… - Aids, 2013 - journals.lww.com
Objective: HIV-infected patients with treated cryptococcal meningitis are at risk for further
neurological deterioration after commencing combination antiretroviral therapy (cART) …

Plasma but not cerebrospinal fluid interleukin 7 and interleukin 5 levels pre–antiretroviral therapy commencement predict cryptococcosis-associated immune …

NA Akilimali, CC Chang, DM Muema… - Clinical Infectious …, 2017 - academic.oup.com
Background Patients with human immunodeficiency virus/AIDS-associated cryptococcal
meningitis (CM) frequently experience clinical deterioration, known as cryptococcosis …

Immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis: a prospective study

T Bicanic, G Meintjes, K Rebe, A Williams… - JAIDS Journal of …, 2009 - journals.lww.com
Background: Prospective data on incidence, characteristics, and risk factors for cryptococcal
meningitis immune reconstitution inflammatory syndrome (CM-IRIS) are lacking. Methods …

Cryptococcosis-IRIS is Associated With Lower Cryptococcus-specific IFN-γ Responses Before Antiretroviral Therapy but Not Higher T-Cell Responses During …

CC Chang, A Lim, S Omarjee, SM Levitz… - The Journal of …, 2013 - academic.oup.com
Background. Cryptococcosis-associated immune reconstitution inflammatory syndrome (C-
IRIS) may be driven by aberrant T-cell responses against cryptococci. We investigated this in …

Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome

DR Boulware, SC Bonham, DB Meya… - The Journal of …, 2010 - academic.oup.com
Abstract Background. Cryptococcal meningitis (CM)-related immune reconstitution
inflammatory syndrome (IRIS) complicates antiretroviral therapy (ART) in 20%–40% of ART …

[HTML][HTML] Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study

DR Boulware, DB Meya, TL Bergemann… - PLoS …, 2010 - journals.plos.org
Background Although antiretroviral therapy (ART) improves survival in persons with
cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution …

Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes

JN Jarvis, T Bicanic, A Loyse… - Clinical infectious …, 2014 - academic.oup.com
Background. Cryptococcal meningitis (CM) is a leading cause of death in individuals
infected with human immunodeficiency virus (HIV). Identifying factors associated with …

Recurrence of symptoms following cryptococcal meningitis: characterizing a diagnostic conundrum with multiple etiologies

NC Bahr, CP Skipper, K Huppler-Hullsiek… - Clinical Infectious …, 2023 - academic.oup.com
Background Cryptococcal meningitis is a common cause of AIDS-related mortality. Although
symptom recurrence after initial treatment is common, the etiology is often difficult to …

[HTML][HTML] Cryptococcal immune reconstitution inflammatory syndrome: from blood and cerebrospinal fluid biomarkers to treatment approaches

VMS Brienze, JC André, E Liso, I Vlasova-St. Louis - Life, 2021 - mdpi.com
Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune
reaction that occurs during dysregulated immune restoration in immunocompromised …

Cellular immune activation in cerebrospinal fluid from Ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome

DB Meya, S Okurut, G Zziwa, MA Rolfes… - The Journal of …, 2015 - academic.oup.com
Background. Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM)
is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid …