New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose

M Nazıroğlu - Neurochemical research, 2007 - Springer
Abstract The Na+ and Ca 2+-permeable melastatin related transient receptor potential
(TRPM2) cation channels can be gated either by ADP-ribose (ADPR) in concert with Ca 2+ …

A calcium influx pathway regulated separately by oxidative stress and ADP-Ribose in TRPM2 channels: single channel events

M Nazıroğlu, A Lückhoff - Neurochemical research, 2008 - Springer
A melastatin-like transient receptor potential 2 (TRPM2) channel is activated in concert with
Ca 2+ by intracellular adenosine diphosphoribose (ADPR) binding to the channel's enzyme …

TRPM2 cation channels, oxidative stress and neurological diseases: where are we now?

M Nazıroğlu - Neurochemical research, 2011 - Springer
Abstract The Na+ and Ca 2+-permeable melastatin related transient receptor potential 2
(TRPM2) channels can be gated either by ADP-ribose (ADPR) in concert with Ca 2+ or by …

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel

B Tóth, L Csanády - Journal of Biological Chemistry, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable cation channel
involved in physiological and pathophysiological processes linked to oxidative stress …

Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen peroxide

M Nazıroğlu, A Lückhoff - Journal of the neurological sciences, 2008 - Elsevier
Melastatin-like transient receptor potential 2 (TRPM2) channel is a redox sensitive Ca2+-
permeable cation channel that can be gated by H2O2 binding to the channel's enzymatic …

Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels

M Kolisek, A Beck, A Fleig, R Penner - Molecular cell, 2005 - cell.com
The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane
Ca 2+-permeable cation channel that is activated by intracellular adenosine …

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels

AL Perraud, CL Takanishi, B Shen, S Kang… - Journal of Biological …, 2005 - ASBMB
TRPM2 is a member of the transient receptor potential melastatin-related (TRPM) family of
cation channels, which possesses both ion channel and ADP-ribose hydrolase functions …

TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose

FJP Kühn, I Heiner, A Lückhoff - Pflügers Archiv, 2005 - Springer
A unique functional property within the transient receptor potential (TRP) family of cation
channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR) …

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

J Du, J Xie, L Yue - Proceedings of the National Academy of …, 2009 - National Acad Sciences
Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca2+-permeable,
nonselective cation channel that is involved in oxidative stress-induced cell death and …

Ca2+‐dependent induction of TRPM2 currents in hippocampal neurons

ME Olah, MF Jackson, H Li, Y Perez… - The Journal of …, 2009 - Wiley Online Library
TRPM2 is a Ca2+‐permeable member of the transient receptor potential melastatin family of
cation channels whose activation by reactive oxygen/nitrogen species (ROS/RNS) and ADP …