The levels of 3 bone resorptive cytokines, interleukin 1α (IL‐1α), IL‐1β, and tumor necrosis
factor α (TNFα), were assessed in tissues from sites of periodontal disease. As determined …

Interleukin‐1β (IL‐1β) is the predominant form of IL‐1 produced by macrophages. IL‐1β
possesses numerous and diverse biological activities. Several of these activities, including …

Interleukin Iβ is a potent bone resorptive cytokine which also mediates soft tissue destruction
through the stimulation of prostaglandin production, and the induction of collagenase and …

This review discusses the effects of interleukin-1 (IL-1) on bone metabolism and the
evidence implicating IL-1 in periodontal disease. IL-1 is a potent cytokine with significant …

Periodontal disease is a significant cause of tooth loss in humans and is one of the most
prevalent diseases associated with bone loss. Following bacterial colonization, the gingiva …

The bone‐resorptive cytokines interleukin 1 (IL‐1) and tumor necrosis factor (TNF) have
been implicated in the pathogenesis of many chronic inflammatory diseases, including …

The extracellular release of IL‐1β by cultured peripheral blood monocytes from 26
periodontitis patients and 26 control subjects was measured by radioimmunoassay …

Periapical bone destruction is an important pathogenic sequela of pulpal infection. Recent
findings from this laboratory have demonstrated that most bone‐resorbing activity in extracts …

Human gingival tissues from periodontitis patients were found to contain from 126 fg/mg to
2161 fg/mg interleukin‐1 beta as determined by a sensitive enzyme linked immunoassay …

Samples of gingival crevicular fluid (GCF) were harvested from sites manifesting features
characteristic of active disease including inflammation, periodontal attachment loss, and …