Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma

Z Hamidov, A Altendorf-Hofmann, Y Chen… - Journal of clinical …, 2011 - jcp.bmj.com
Background Cell–cell adhesion molecules such as desmosomes and cytokeratins may play
a major role in epithelial–mesenchymal transition and have been suggested to have a …

Reduced membranous and ectopic cytoplasmic expression of DSC2 in esophageal squamous cell carcinoma: an independent prognostic factor

WK Fang, W Gu, EM Li, ZY Wu, ZY Shen, JH Shen… - Human pathology, 2010 - Elsevier
Desmocollin 2, a desmosomal component, is a key membrane glycoprotein critically
involved in cell-cell adhesion and the maintenance of normal tissue architectures in …

[HTML][HTML] Desmocollin-2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma via the ERK/c-MYC signaling pathway

B He, L Guo, Y Hu, H Huang, L Wan, K Xu… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common cancers around the world with
a poor prognosis. The main reason for poor prognosis is early stage HCC is inconspicuous …

The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients

F Reimer, S Bryan, K Legler, T Karn… - Cancer Cell …, 2023 - Springer
Background The disruption of epithelial features represents a critical step during breast
cancer spread. In this context, the dysregulation of desmosomal proteins has been …

[HTML][HTML] Regulation of desmocollin3 expression by promoter hypermethylation is associated with advanced esophageal adenocarcinomas

Q Wang, DF Peng, S Zhu, Z Chen, TL Hu… - Journal of …, 2014 - ncbi.nlm.nih.gov
BACKGROUND: Desmocollin3 (DSC3) is a member of the cadherin superfamily of calcium-
dependent cell adhesion molecules and plays an important role in tumor invasion and …

Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma

S Ormanns, A Altendorf-Hofmann, R Jackstadt… - British journal of …, 2015 - nature.com
Background: Frequent disease relapse and a lack of effective therapies result in a very poor
outcome in pancreatic ductal adenocarcinoma (PDAC) patients. Thus, identification of …

Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer

T Cui, L Yang, Y Ma, I Petersen, Y Chen - Experimental cell research, 2019 - Elsevier
Abstract Desmocollin 3 (DSC3) is a transmembrane adhesion protein of desmosomes and
involved in carcinogenesis in various cancer types. Downregulation of DSC3 has been …

Association of DSC3 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis

J Pan, Y Chen, C Mo, D Wang, J Chen, X Mao, S Guo… - PloS one, 2014 - journals.plos.org
Background Desmocollin 3 (DSC3), a member of the cadherin gene superfamily, is
associated with pathogenesis of some cancers, but its role in prostate cancer (PCa) remains …

Transcriptomic profiling identifies DCBLD2 as a diagnostic and prognostic biomarker in pancreatic ductal adenocarcinoma

Z Feng, K Li, Y Wu, C Peng - Frontiers in molecular biosciences, 2021 - frontiersin.org
Background: Accumulating evidence shows that the elevated expression of DCBLD2
(discoidin, CUB and LCCL domain-containing protein 2) is associated with unfavorable …

Desmoplastic crosstalk in pancreatic ductal adenocarcinoma is reflected by different responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 cell lines to cancer …

Š Novák, M Kolář, A Szabo, Z Vernerova… - Cancer Genomics & …, 2021 - cgp.iiarjournals.org
Background/Aim: Pancreatic ductal adenocarcinoma (PDAC) still represents one of the most
aggressive cancers. Understanding of the epithelial–mesenchymal crosstalk as a crucial …