Human monoclonal antibody derived from transchromosomic cattle neutralizes multiple H1 clades of influenza A virus by recognizing a novel conformational epitope …
Influenza remains a global health risk and challenge. Currently, neuraminidase (NA)
inhibitors are extensively used to treat influenza, but their efficacy is compromised by the …
inhibitors are extensively used to treat influenza, but their efficacy is compromised by the …
Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza A virus subtype H5N1
S Maneewatch, J Thanongsaksrikul… - Antiviral …, 2009 - journals.sagepub.com
Background Human antibodies that interfere with the biological activity of haemagglutinins
(HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single …
(HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single …
[HTML][HTML] Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice
S Son, SB Ahn, G Kim, Y Jang, C Ko, M Kim, SJ Kim - Antiviral Research, 2023 - Elsevier
Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus
enable it to cross the species barrier, threatening public health with the risk of pandemics …
enable it to cross the species barrier, threatening public health with the risk of pandemics …
A cross-clade H5N1 influenza A virus neutralizing monoclonal antibody binds to a novel epitope within the vestigial esterase domain of hemagglutinin
The sporadic outbreaks of highly pathogenic H5N1 avian influenza virus have raised public
health concerns. Monoclonal antibodies (MAbs) against hemagglutinin (HA) have been …
health concerns. Monoclonal antibodies (MAbs) against hemagglutinin (HA) have been …
Generation and characterization of monoclonal antibodies against the hemagglutinin of H3N2 influenza A viruses
F Yang, L Zhu, F Liu, L Cheng, H Yao, N Wu, H Wu, L Li - Virus Research, 2022 - Elsevier
Seasonal influenza viruses are highly contagious, leading to 290,000–650,000 mortalities
every year globally. Among the influenza viruses, influenza A virus (H3N2) has attracted …
every year globally. Among the influenza viruses, influenza A virus (H3N2) has attracted …
A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses
Influenza A virus infection is a persistent threat to public health worldwide due to its ability to
evade immune surveillance through rapid genetic drift and shift. Current vaccines against …
evade immune surveillance through rapid genetic drift and shift. Current vaccines against …
A novel humanized antibody neutralizes H5N1 influenza virus via two different mechanisms
Y Tan, Q Ng, Q Jia, J Kwang, F He - Journal of Virology, 2015 - Am Soc Microbiol
Highly pathogenic avian influenza virus subtype H5N1 continues to be a severe threat to
public health, as well as the poultry industry, because of its high lethality and antigenic drift …
public health, as well as the poultry industry, because of its high lethality and antigenic drift …
Humanized antibodies with broad-spectrum neutralization to avian influenza virus H5N1
Hemagglutinin (HA), the major antigen on the surface of influenza viruses, is the primary
target for neutralizing antibodies and vaccine design. However, frequent mutations in this …
target for neutralizing antibodies and vaccine design. However, frequent mutations in this …
Neutralizing and protective murine monoclonal antibodies to the hemagglutinin of influenza H5 clades 2.3. 2.1 and 2.3. 4.4
C Schuele, F Schmeisser, M Orr… - Influenza and Other …, 2023 - Wiley Online Library
Background Highly pathogenic avian H5 influenza viruses have spread and diversified
genetically and antigenically into multiple clades and subclades. Most isolates of currently …
genetically and antigenically into multiple clades and subclades. Most isolates of currently …
A fully human monoclonal antibody possesses antibody‐dependent cellular cytotoxicity (ADCC) activity against the H1 subtype of influenza A virus by targeting a …
The DiversitabTM system produces target specific high titer fully human polyclonal IgG
immunoglobulins from transchromosomic (Tc) bovines shown to be safe and effective …
immunoglobulins from transchromosomic (Tc) bovines shown to be safe and effective …
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