Human monoclonal antibody derived from transchromosomic cattle neutralizes multiple H1 clades of influenza A virus by recognizing a novel conformational epitope …

R Gao, CC Sreenivasan, Z Sheng, BM Hause… - Journal of …, 2020 - Am Soc Microbiol
Influenza remains a global health risk and challenge. Currently, neuraminidase (NA)
inhibitors are extensively used to treat influenza, but their efficacy is compromised by the …

Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza A virus subtype H5N1

S Maneewatch, J Thanongsaksrikul… - Antiviral …, 2009 - journals.sagepub.com
Background Human antibodies that interfere with the biological activity of haemagglutinins
(HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single …

[HTML][HTML] Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice

S Son, SB Ahn, G Kim, Y Jang, C Ko, M Kim, SJ Kim - Antiviral Research, 2023 - Elsevier
Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus
enable it to cross the species barrier, threatening public health with the risk of pandemics …

A cross-clade H5N1 influenza A virus neutralizing monoclonal antibody binds to a novel epitope within the vestigial esterase domain of hemagglutinin

SS Paul, CK Mok, TM Mak, OW Ng, JO Aboagye… - Antiviral research, 2017 - Elsevier
The sporadic outbreaks of highly pathogenic H5N1 avian influenza virus have raised public
health concerns. Monoclonal antibodies (MAbs) against hemagglutinin (HA) have been …

Generation and characterization of monoclonal antibodies against the hemagglutinin of H3N2 influenza A viruses

F Yang, L Zhu, F Liu, L Cheng, H Yao, N Wu, H Wu, L Li - Virus Research, 2022 - Elsevier
Seasonal influenza viruses are highly contagious, leading to 290,000–650,000 mortalities
every year globally. Among the influenza viruses, influenza A virus (H3N2) has attracted …

A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses

H Hu, J Voss, G Zhang, P Buchy, T Zuo, L Wang… - Journal of …, 2012 - Am Soc Microbiol
Influenza A virus infection is a persistent threat to public health worldwide due to its ability to
evade immune surveillance through rapid genetic drift and shift. Current vaccines against …

A novel humanized antibody neutralizes H5N1 influenza virus via two different mechanisms

Y Tan, Q Ng, Q Jia, J Kwang, F He - Journal of Virology, 2015 - Am Soc Microbiol
Highly pathogenic avian influenza virus subtype H5N1 continues to be a severe threat to
public health, as well as the poultry industry, because of its high lethality and antigenic drift …

Humanized antibodies with broad-spectrum neutralization to avian influenza virus H5N1

Y Chen, W Luo, WL Wu, Z Fang, L Xia, X Gui, Y Chen… - Antiviral research, 2010 - Elsevier
Hemagglutinin (HA), the major antigen on the surface of influenza viruses, is the primary
target for neutralizing antibodies and vaccine design. However, frequent mutations in this …

Neutralizing and protective murine monoclonal antibodies to the hemagglutinin of influenza H5 clades 2.3. 2.1 and 2.3. 4.4

C Schuele, F Schmeisser, M Orr… - Influenza and Other …, 2023 - Wiley Online Library
Background Highly pathogenic avian H5 influenza viruses have spread and diversified
genetically and antigenically into multiple clades and subclades. Most isolates of currently …

A fully human monoclonal antibody possesses antibody‐dependent cellular cytotoxicity (ADCC) activity against the H1 subtype of influenza A virus by targeting a …

R Gao, Z Wang, T Uprety… - Journal of Medical …, 2023 - Wiley Online Library
The DiversitabTM system produces target specific high titer fully human polyclonal IgG
immunoglobulins from transchromosomic (Tc) bovines shown to be safe and effective …