Transforming growth factor beta (TGF-β) is a polypeptide found in high concentrations in
bone and is produced by and acts on primary adult human derived osteoblast-enriched …

Although initially purified from platelets,'two distinct forms of TGFP have been purified from
bone. In fact, the second form, TGFP-I1 was identified initially in bone.'.'These two bone …

Bone formation results from the anabolic and catabolic functions of osteoblasts and
osteoclasts within bone. The activities of these cell populations are controlled by complex …

Transforming growth factor β (TGF-β) has been shown to induce chondrogenesis by
embryonic rat mesenchymal cells (Seyedin et al., J. Biol. Chem., 261: 5693, 1986). Here we …

Normal skeletal growth results from a balance between the processes of bone matrix
synthesis and resorption. These activities are regulated by both systemic and local factors …

Transforming growth factor-beta (TGF-β) plays a critical role in bone remodeling. TGF-β
stimulates matrix protein synthesis, has dramatic effects on the bone cells responsible for …

Transforming growth factors (TGF‐β1 and TGF‐β2) are polypeptide growth factors with a
wide range of effects on the growth and differentiated function of a variety of cell types …

At first reading the statement “TGFβ stimulates bone formation but inhibits mineralization”
may appear to be an oxymoron. However, the bone formation process can take weeks to …

Bone has been shown to store large amounts of transforming growth factor type beta (TGFβ)
and this has recently been found to be synthesized by bone‐forming cells. We report on …

The complexity of the fracture repair process has been apparent to both clinicians and
scientists since its first histologic description. How fracture repair is regulated, however …