Horizontal transfer of antibiotic resistance genes in the human gut microbiome
Highlights•The human gut microbiome harbours antibiotic resistance genes ('the
resistome').•Antibiotic resistance genes can spread in the gut microbiome through horizontal …
resistome').•Antibiotic resistance genes can spread in the gut microbiome through horizontal …
Probiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner
Antimicrobial resistance poses a substantial threat to human health. The gut microbiome is
considered a reservoir for potential spread of resistance genes from commensals to …
considered a reservoir for potential spread of resistance genes from commensals to …
Global environmental resistome: Distinction and connectivity across diverse habitats benchmarked by metagenomic analyses
The widely distributed antibiotic resistance genes (ARGs) were unevenly proliferated in
various habitats. Great endeavors are needed to resolve the resistome features that can …
various habitats. Great endeavors are needed to resolve the resistome features that can …
[HTML][HTML] Exploration of the antibiotic resistome in a wastewater treatment plant by a nine-year longitudinal metagenomic study
The spread of antibiotic resistance genes (ARGs) is a growing global problem. Activated
sludge (AS) in wastewater treatment plants (WWTPs) has been proposed as a hotspot for …
sludge (AS) in wastewater treatment plants (WWTPs) has been proposed as a hotspot for …
Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs
EC Pehrsson, KJ Forsberg, MK Gibson… - Frontiers in …, 2013 - frontiersin.org
Rates of infection with antibiotic-resistant bacteria have increased precipitously over the past
several decades, with far-reaching healthcare and societal costs. Recent evidence has …
several decades, with far-reaching healthcare and societal costs. Recent evidence has …
Next-generation approaches to understand and combat the antibiotic resistome
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
Coexistence of antibiotic resistance genes and virulence factors deciphered by large-scale complete genome analysis
Widespread use of antibiotics has enhanced the evolution of highly resilient pathogens and
poses a severe risk to human health via coselection of antibiotic resistance genes (ARGs) …
poses a severe risk to human health via coselection of antibiotic resistance genes (ARGs) …
Antibiotic resistance gene diversity and virulence gene diversity are correlated in human gut and environmental microbiomes
Human beings have used large amounts of antibiotics, not only in medical contexts but also,
for example, as growth factors in agriculture and livestock, resulting in the contamination of …
for example, as growth factors in agriculture and livestock, resulting in the contamination of …
A bioinformatic analysis of integrative mobile genetic elements highlights their role in bacterial adaptation
Mobile genetic elements (MGEs) contribute to bacterial adaptation and evolution; however,
high-throughput, unbiased MGE detection remains challenging. We describe MGEfinder, a …
high-throughput, unbiased MGE detection remains challenging. We describe MGEfinder, a …
The association between insertion sequences and antibiotic resistance genes
M Razavi, E Kristiansson, CF Flach, DGJ Larsson - Msphere, 2020 - Am Soc Microbiol
Insertion sequences (ISs) are abundant mobile genetic elements on bacterial genomes,
responsible for mobilization of many genes, including antibiotic resistance genes (ARGs). As …
responsible for mobilization of many genes, including antibiotic resistance genes (ARGs). As …