Importance of mobile genetic elements for dissemination of antimicrobial resistance in metagenomic sewage samples across the world

MHK Johansson, FM Aarestrup, TN Petersen - Plos one, 2023 - journals.plos.org
We are facing an ever-growing threat from increasing antimicrobial resistance (AMR) in
bacteria. To mitigate this, we need a better understanding of the global spread of …

Gain and loss of antibiotic resistant genes in multidrug resistant bacteria: One Health perspective

M Kim, J Park, M Kang, J Yang, W Park - Journal of microbiology, 2021 - Springer
The emergence of multidrug resistance (MDR) has become a global health threat due to the
increasing unnecessary use of antibiotics. Multidrug resistant bacteria occur mainly by …

Exploring the animal waste resistome: the spread of antimicrobial resistance genes through the use of livestock manure

A Checcucci, P Trevisi, D Luise, M Modesto… - Frontiers in …, 2020 - frontiersin.org
Antibiotic resistance is a public health problem of growing concern. Animal manure
application to soil is considered to be a main cause of the propagation and dissemination of …

Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals

Y Duan, Z Chen, L Tan, X Wang, Y Xue, S Wang… - Science of the Total …, 2020 - Elsevier
Human gut microbiota is an important reservoir of antibiotic resistance genes (ARGs).
Although dysbacteriosis after the antibiotic course has been previously observed in the …

Characterization of the pig gut microbiome and antibiotic resistome in industrialized feedlots in China

C Wang, P Li, Q Yan, L Chen, T Li, W Zhang, H Li… - Msystems, 2019 - Am Soc Microbiol
To characterize the diversity and richness and explore the function and structure of swine
gut microbiome and resistome in common pig-farming feedlots, we sampled and …

[HTML][HTML] Metagenomic insights into differences in environmental resistome profiles between integrated and monoculture aquaculture farms in China

C Xu, Z Lv, Y Shen, D Liu, Y Fu, L Zhou, W Liu… - Environment …, 2020 - Elsevier
Cumulative research on resistomes and microbiomes from aquatic environments has
revealed that both integrated freshwater and monoculture freshwater aquaculture systems …

Identification and reconstruction of novel antibiotic resistance genes from metagenomes

F Berglund, T Österlund, F Boulund, NP Marathe… - Microbiome, 2019 - Springer
Background Environmental and commensal bacteria maintain a diverse and largely
unknown collection of antibiotic resistance genes (ARGs) that, over time, may be mobilized …

The antibiotic resistome

GD Wright - Expert opinion on drug discovery, 2010 - Taylor & Francis
Importance of the field: Antibiotics are essential for the treatment of bacterial infections and
are among our most important drugs. Resistance has emerged to all classes of antibiotics in …

Large-scale metagenomic-based study of antibiotic resistance in the environment

J Nesme, S Cécillon, TO Delmont, JM Monier… - Current biology, 2014 - cell.com
Antibiotic resistance, including multiresistance acquisition and dissemination by pathogens,
is a critical healthcare issue threatening our management of infectious diseases [1–3]. Rapid …

What is a resistance gene? Ranking risk in resistomes

JL Martínez, TM Coque, F Baquero - Nature Reviews Microbiology, 2015 - nature.com
Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the
environment, which has led to the suggestion that there is a high risk that these genes will …