Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or
an antibody fragment. Conjugation can be obtained by chemical or genetic engineering …

Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused
to a targeting moiety. Various toxic agents from different sources are used in immunotoxin …

The concept of “magic bullets”, ie, drugs able to selectively act on target cells, formulated by
Paul Ehrlich more than one century ago, gave rise to the idea of immunotargeting, one of the …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

Immunotoxins (ITs) are chimeric molecules constructed by covalently conjugating
monoclonal antibodies (MoAbs) to plant or bacterial toxins (eg ricin or pseudomonas …

Drug targeting is an attractive new approach to killing malignant cells, thereby leaving
normal tissue unharmed. A decisive breakthrough was the advent of hybridoma technology …

Bacterial-and plant-derived immunotoxins have documented potential for treatment of
cancer. We discuss Anthrax toxin, ribosome inactivating-toxins, such as saporin and ricin …

Molecular farming in plants is an emerging platform for the production of pharmaceutical
proteins, and host species such as tobacco are now becoming competitive with …

When conjugated with antibodies that bind selectively to tumor cells, natural toxins from
plants and bacteria represent a potentially powerful form of cancer therapy. Over the last …

Chemotherapy, radiation, and surgery are the conventional treatment modalities for cancer.
The success achieved with these approaches has been limited due to several factors like …