Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …

Although guanosine is an endogenous nucleoside that displays antidepressant-like
properties in several animal models, the mechanism underlying its antidepressant-like …

Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but
the mechanisms underlying its effect are not well established. We investigated if the …

Guanosine is a purine nucleoside that occurs naturally in the central nervous system,
exerting trophic effects. Given its neuroprotective properties, the potential of guanosine as …

The activation of AMPA receptors and mTOR signaling has been reported as mechanisms
underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor …

Guanosine is a guanine-based purine that modulates glutamate uptake and exerts
neurotrophic and neuroprotective effects. In a previous study, our group demonstrated that …

Atorvastatin is a synthetic and lipophilic statin that presents a good effect in decreasing
cholesterol levels and is safe and well tolerated. Population-based studies have suggested …

We have previously shown that an acute administration of adenosine produces an
antidepressant-like effect in the forced swimming test (FST) and in the tail suspension test in …

L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) is an important
signaling pathway involved in depression. With this information, the present study aimed to …

Antidepressant-like effects of 5-hydroxytryptamine subtype 3 (5-HT 3) antagonists including
tropisetron and ondansetron have been previously demonstrated in the literature. It was …