Bioassay-based risk assessment of complex mixtures
KC Donnelly, SH Safe, K Randerath… - Journal of hazardous …, 1995 - Elsevier
In order to compare a standard chemical-based risk assessment with in vitro genotoxicity
assays, two complex environmental mixtures from a wood-preserving site were analyzed in …
assays, two complex environmental mixtures from a wood-preserving site were analyzed in …
Toxicity characterization of complex mixtures using biological and chemical analysis in preparation for assessment of mixture similarity
L Cizmas, TJ McDonald, TD Phillips… - … science & technology, 2004 - ACS Publications
In the United States, several proposed approaches for using bioassays for the risk
assessment of complex hazardous mixtures require that selected mixtures be “sufficiently …
assessment of complex hazardous mixtures require that selected mixtures be “sufficiently …
A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysis
Chemical fractionation is a widely used tool for the chemical and toxicological
characterization of complex mixtures. The objective of this research was to compare two …
characterization of complex mixtures. The objective of this research was to compare two …
Bioassay-based risk assessment of complex mixtures
KC Donnelly¹, HJ Huebner - Superfund Risk Assessment in Soil …, 1996 - books.google.com
The baseline risk assessment often plays an integral role in various decision-making
processes at Superfund sites. The present study reports on risk characterizations prepared …
processes at Superfund sites. The present study reports on risk characterizations prepared …
Genotoxicity of complex PAH mixtures recovered from contaminated lake sediments as assessed by three different methods
K Randerath, E Randerath, GD Zhou… - Environmental and …, 1999 - Wiley Online Library
Although human exposure generally occurs to mixtures of chemicals, limited toxicological
information is available to characterize the potential interactions of the components of …
information is available to characterize the potential interactions of the components of …
Application of a semi-automated SOS chromotest for measuring genotoxicities of complex environmental mixtures containing polycyclic aromatic hydrocarbons
L Nylund, E Hakala, M Sorsa - Mutation Research/Reviews in Genetic …, 1992 - Elsevier
Soxhlet-extracted samples of standard reference materials (SRMs) 1649 (PART: urban
dust/organics) and 1650 (PAR2: diesel particulate matter) from the US Institute of Standards …
dust/organics) and 1650 (PAR2: diesel particulate matter) from the US Institute of Standards …
Overview, conclusions, and recommendations of the IPCS collaborative study on complex mixtures
LD Claxton, G Douglas, D Krewski, J Lewtas… - … Research/Reviews in …, 1992 - Elsevier
Abstract The International Programme on Chemical Safety (IPCS) sponsored an
international collaborative study to examine the variability associated with the extraction and …
international collaborative study to examine the variability associated with the extraction and …
Molecular dosimetry of DNA damage induced by polycyclic aromatic hydrocarbons; relevance for exposure monitoring and risk assessment
RA Baan, MJST Steenwinkel… - Human & …, 1994 - journals.sagepub.com
Polycyclic aromatic hydrocarbons (PAH) form a large group of organic chemicals that are
widely distributed in our environment as pollutants of air, water and soil. Several PAH are …
widely distributed in our environment as pollutants of air, water and soil. Several PAH are …
[HTML][HTML] In vitro genotoxicity evaluation of PAHs in mixtures using experimental design
R Castel, V Tassistro, M Claeys-Bruno, L Malleret… - Toxics, 2023 - mdpi.com
Settled dusts are sinks for environmental pollutants, including Polycyclic Aromatic
Hydrocarbons (PAHs) that are ubiquitous, persistent, and carcinogenic. To assess their …
Hydrocarbons (PAHs) that are ubiquitous, persistent, and carcinogenic. To assess their …
The genotoxicity of priority polycyclic aromatic hydrocarbons in complex mixtures
PA White - Mutation Research/Genetic Toxicology and …, 2002 - Elsevier
Risk assessment of complex environmental samples suffers from difficulty in identifying toxic
components, inadequacy of available toxicity data, and a paucity of knowledge about the …
components, inadequacy of available toxicity data, and a paucity of knowledge about the …