Normothermic kidney preservation

A Weissenbacher - 2018 - ora.ox.ac.uk
The thesis describes the development of a transportable normothermic kidney preservation
device which is able to perfuse discarded human and porcine kidneys for up to 24 hours for …

[HTML][HTML] Twenty-four–hour normothermic perfusion of discarded human kidneys with urine recirculation

A Weissenbacher, LL Faro, O Boubriak… - American Journal of …, 2019 - Elsevier
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability
assessment of marginal grafts, increased organ use, and improved transplant logistics …

Deceased donor kidney function is determined by branch chained amino acid metabolism during ex vivo normothermic perfusion

A Ahmadi, JMU Yu, JE Loza, BC Howard, I Palma… - medRxiv, 2023 - medrxiv.org
Current kidney perfusion protocols are not optimized for addressing the ex vivo
physiological and metabolic needs of the kidney. Ex vivo normothermic perfusion (EVNP) …

[HTML][HTML] 48 h Normothermic Machine Perfusion With Urine Recirculation for Discarded Human Kidney Grafts

F Messner, A Soleiman, D Öfner… - Transplant …, 2023 - frontierspartnerships.org
Background: Normothermic machine perfusion (NMP) has reshaped organ preservation in
recent years. In this preclinical study, prolonged normothermic perfusions of discarded …

[HTML][HTML] Urine recirculation prolongs normothermic kidney perfusion via more optimal metabolic homeostasis—a proteomics study

A Weissenbacher, H Huang, T Surik, MLL Faro… - American Journal of …, 2021 - Elsevier
We describe a proteomics analysis to determine the molecular differences between
normothermically perfused (normothermic machine perfusion, NMP) human kidneys with …

Urine recirculation improves hemodynamics and enhances function in normothermic kidney perfusion

A Weissenbacher, D Voyce, CDL Ceresa… - Transplantation …, 2020 - journals.lww.com
Background. The study compares urine recirculation (URC) to urine replacement (UR) with
Ringer's lactate in a porcine normothermic kidney machine perfusion (NMP) model using a …

Kidney perfusion: some like it hot others prefer to keep it cool

I Jochmans, ML Nicholson… - Current Opinion in Organ …, 2017 - journals.lww.com
A great deal of research is still needed to optimize and logistically place hypothermic and
normothermic perfusion technologies. In the future, we may progress toward organ-tailored …

Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion

PPW Luke, L Jiang, A Ruthirakanthan… - Journal of …, 2022 - Taylor & Francis
Objective We have previously demonstrated benefits of kidney preservation utilizing an
oxygenated subnormothermic ex vivo perfusion platform. Herein, we aim to compare …

Normothermic ex vivo perfusion of deceased donor kidneys and its clinical potential in kidney transplantation outcomes

M Unes, K Kurashima, Y Caliskan… - … Journal of Artificial …, 2023 - journals.sagepub.com
In recent years, normothermic machine perfusion (NMP) has emerged in conversation
surrounding organ preservation and transplantation techniques with the goal of improving …

[HTML][HTML] Hemodynamics and metabolic parameters in normothermic kidney preservation are linked with donor factors, perfusate cells, and cytokines

A Weissenbacher, JP Stone, ML Lo Faro… - Frontiers in …, 2022 - frontiersin.org
Kidney transplantation is the best renal-replacement option for most patients with end-stage
renal disease. Normothermic machine preservation (NMP) of the kidney has been studied …