Transcription factor IIH (TFIIH) participates in transcription, nucleotide excision repair and
the control of the cell cycle. In the present study, we demonstrate that the Dmp52 subunit of …

Mutations in XPB and XPD TFIIH helicases have been related with three hereditary human
disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. The dual …

The tumor suppressor function of p53 has been attributed to its ability to regulate apoptosis
and the cell cycle. In mammals, DNA damage, aberrant growth signals, chemotherapeutic …

Programmed cell death (apoptosis) is a conserved process aimed to eliminate unwanted
cells. The key molecules are a group of proteases called caspases that cleave vital proteins …

Exposure to genotoxic stress promotes cell cycle arrest and DNA repair or apoptosis. These
“life” or “death” cell fate decisions often rely on the activity of the tumor suppressor gene p53 …

We have used genetic and microarray analysis to determine how ionizing radiation (IR)
induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces …

The transcription and DNA repair factor TFIIH is composed of 10 subunits. Mutations in the
XPB, XPD, and p8 subunits are genetically linked to human diseases, including cancer …

In Drosophila, the checkpoint protein-2 kinase (DmChk2) and its downstream effector
protein, Dmp53, are required for DNA damage-mediated cell cycle arrest, DNA repair and …

p53 is a representative tumor suppressor whose dysfunction is a major cause of human
cancer syndrome. Here we isolated flies lacking Dmp53, which encodes the single …

The cellular antioxidant defense systems neutralize the cytotoxic by-products referred to as
reactive oxygen species (ROS). Among them, selenoproteins have important antioxidant …