Unsupervised data-driven stratification of mentalizing heterogeneity in autism
Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous.
Novel approaches are needed to parse this heterogeneity to enhance precision in clinical …
Novel approaches are needed to parse this heterogeneity to enhance precision in clinical …
Toward neurosubtypes in autism
There is a consensus that substantial heterogeneity underlies the neurobiology of autism
spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of …
spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of …
Assessment of neuroanatomical endophenotypes of autism spectrum disorder and association with characteristics of individuals with schizophrenia and the general …
G Hwang, J Wen, S Sotardi, ES Brodkin… - JAMA …, 2023 - jamanetwork.com
Importance Autism spectrum disorder (ASD) is associated with significant clinical,
neuroanatomical, and genetic heterogeneity that limits precision diagnostics and treatment …
neuroanatomical, and genetic heterogeneity that limits precision diagnostics and treatment …
Robust, generalizable, and interpretable artificial intelligence–derived brain fingerprints of autism and social communication symptom severity
Background Autism spectrum disorder (ASD) is among the most pervasive
neurodevelopmental disorders, yet the neurobiology of ASD is still poorly understood …
neurodevelopmental disorders, yet the neurobiology of ASD is still poorly understood …
Fractionating autism based on neuroanatomical normative modeling
Autism is a complex neurodevelopmental condition with substantial phenotypic, biological,
and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism …
and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism …
Contrastive machine learning reveals the structure of neuroanatomical variation within autism
Autism spectrum disorder (ASD) is highly heterogeneous. Identifying systematic individual
differences in neuroanatomy could inform diagnosis and personalized interventions. The …
differences in neuroanatomy could inform diagnosis and personalized interventions. The …
[HTML][HTML] Dissecting the heterogeneous cortical anatomy of autism spectrum disorder using normative models
Background The neuroanatomical basis of autism spectrum disorder (ASD) has remained
elusive, mostly owing to high biological and clinical heterogeneity among diagnosed …
elusive, mostly owing to high biological and clinical heterogeneity among diagnosed …
Revealing the selectivity of neuroanatomical alteration in autism spectrum disorder via reverse inference
Background Although neuroimaging research has identified atypical neuroanatomical
substrates in individuals with autism spectrum disorder (ASD), it is at present unclear …
substrates in individuals with autism spectrum disorder (ASD), it is at present unclear …
[HTML][HTML] Reconciling dimensional and categorical models of autism heterogeneity: a brain connectomics and behavioral study
Background Heterogeneity in autism spectrum disorder (ASD) has hindered the
development of biomarkers, thus motivating subtyping efforts. Most subtyping studies divide …
development of biomarkers, thus motivating subtyping efforts. Most subtyping studies divide …
From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder
Pattern classification and stratification approaches have increasingly been used in research
on Autism Spectrum Disorder (ASD) over the last ten years with the goal of translation …
on Autism Spectrum Disorder (ASD) over the last ten years with the goal of translation …