Genetic modification of hematopoietic stem cells (HSCs) resulting in a state of molecular
chimerism can be used to induce donor-specific tolerance to allografts. However, the …

Induction of molecular chimerism through genetic modification of bone marrow is a powerful
tool for the induction of tolerance. Here, we demonstrate for the first time that expression of …

Induction of molecular chimerism following reconstitution of mice with autologous bone
marrow cells expressing a retrovirally encoded allogeneic MHC class I Ag results in donor …

Induction of immunologic tolerance to alloantigens is a major goal in the field of
transplantation. Here, we demonstrate that efficient transduction and expression of a …

Donor-specific transplantation tolerance can be established through the induction of
molecular chimerism following reconstitution of lethally irradiated mice with autologous bone …

Creation of stable hemopoietic chimerism has been considered to be a prerequisite for
allograft tolerance after bone marrow transplantation (BMT). In this study, we demonstrated …

Engrafted allogeneic hematopoietic cells have a unique capacity to induce a state of donor-
specific transplantation tolerance across major histocompatibility complex barriers. This …

Donor hemopoietic cell engraftment is considered to be an indicator of allograft tolerance.
We depleted chimerism with cells specifically presensitized to the bone marrow donor to …

Hematopoietic chimerism has been used in the laboratory to induce life-long immunologic
tolerance to donor antigens. The present study demonstrates that mice transplanted with …

Posttransplant infusion of donor bone marrow cells (BMC) induces tolerance to allografts in
adult mice, dogs, nonhuman primates, and probably humans. Here we used a mouse skin …