Anatomy of adenosine A2A receptors in brain: Morphological substrates for integration of striatal function
A2A adenosine receptors (A2ARs) are expressed with the greatest abundance in the
striatum and other nuclei of the basal ganglia. The segregated expression of A2ARs on the …
striatum and other nuclei of the basal ganglia. The segregated expression of A2ARs on the …
Adenosine A2A receptor in the monkey basal ganglia: Ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum
JW Bogenpohl, SL Ritter, RA Hall… - Journal of Comparative …, 2012 - Wiley Online Library
The adenosine A2A receptor (A2AR) is a potential drug target for the treatment of
Parkinson's disease and other neurological disorders. In rodents, the therapeutic efficacy of …
Parkinson's disease and other neurological disorders. In rodents, the therapeutic efficacy of …
Distribution, biochemistry and function of striatal adenosine A2A receptors
P Svenningsson, C Le Moine, G Fisone… - Progress in …, 1999 - Elsevier
It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …
Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum
Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the function of
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …
[HTML][HTML] Adenosine A2A Receptors and A2A Receptor Heteromers as Key Players in Striatal Function
A very significant density of adenosine A2A receptors (A2ARs) is present in the striatum,
where they are preferentially localized postsynaptically in striatopallidal medium spiny …
where they are preferentially localized postsynaptically in striatopallidal medium spiny …
Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons
SN Schiffmann, JJ Vanderhaeghen - Journal of Neuroscience, 1993 - Soc Neuroscience
Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …
have been recognized, among other effects, as strong depressors of the locomotor activity …
Adenosine receptor neurobiology: overview
Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …
body as a metabolic intermediary. In the brain, adenosine functions as an important …
Adenosine A2A receptors and basal ganglia physiology
Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …
Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat
Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …
Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease
K Fuxe, LF Agnati, K Jacobsen, J Hillion, M Canals… - Neurology, 2003 - AAN Enterprises
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …