Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …

There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …

This brief review presents a personal perspective on the historical development of the
current knowledge about the biologically important concept of functional antagonism …

Adenosine A2A receptors (A2ARs) are highly concentrated in the striatum. Two
pharmacological different functional populations of A2ARs have been recently described …

Basal ganglia processing results from a balanced activation of direct and indirect striatal
efferent pathways, which are controlled by dopamine D1 and D2 receptors, respectively …

The selective localization of adenosine A2A receptors to the striatopallidal system
suggested a new therapeutic approach to the management of Parkinson's disease (PD). The …

A2ARs (adenosine A2A receptors) are highly enriched in the striatum, which is the main
motor control CNS (central nervous system) area. BRET (bioluminescence resonance …

The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs …

The antagonistic interaction between adenosine and dopamine receptors could have
important pathophysiological and therapeutic implications in Parkinson's disease (PD). The …

The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …