Adenosine and caffeine modulate locomotor activity and striatal gene expression, partially
through the activation and blockade of striatal A2A receptors, respectively. The elucidation of …

Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for
the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists …

Striatal adenosine A2A receptors (A2ARs) are highly expressed in medium spiny neurons
(MSNs) of the indirect efferent pathway, where they heteromerize with dopamine D2 …

Electrophysiological recordings in rat brain slices have been used to study the actions of
adenosine on striatal neurons and striatal excitatory amino acid neurotransmission …

In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …

Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

Neurochemical and pharmcological evidence obtained over the past 300 yr has indicated
that adenosine and dopamine interact functionally in the basal ganglia and that such …

Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …

[Frontiers in Bioscience 13, 2391-2399, January 1, 2008] 2391 Adenosine A1-A2A receptor
heteromers: new targets for caffeine in Page 1 [Frontiers in Bioscience 13, 2391-2399, January …

The interaction between adenosine A2A and dopamine D2 receptors in striatal neurons is a
well-established phenomenon and has opened up new perspectives on the molecular …