Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia,
activated by the neuromodulator adenosine, which interact with dopamine D2 receptors …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …

The interest on targeting adenosine A2A receptors in the realm of psychiatric diseases first
arose based on their tight physical and functional interaction with dopamine D2 receptors …

Adenosine–dopamine interactions in the central nervous system (CNS) have been studied
for many years in view of their relevance for disorders of the CNS and their treatments. The …

Adenosine, by acting on adenosine A1 and A2A receptors, exerts opposite modulatory roles
on striatal extracellular levels of glutamate and dopamine, with activation of A1 inhibiting …

The distribution of the messenger RNA coding for the recently cloned adenosine A 2
receptor was studied in the human brain using in situ hybridization histochemistry. A 2 …

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

Adenosine is a neuromodulator mostly acting through A1 (inhibitory) and A2A (excitatory)
receptors in the brain. A2B receptors (A2 BR) are Gs/q‐protein‐coupled receptors with low …

Endogenous adenosine is a widely distributed upstream regulator of a broad spectrum of
neurotransmitters, receptors, and signaling pathways that converge to contribute to the …