The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that stimulates
adenylyl cyclase activity. In the brain, A 2A Rs are found highly enriched in striatal …

The A2A adenosine receptor (AdR) subtype has emerged as an attractive target in the
pursuit of improved therapy for Parkinson's disease (PD). This report focuses on …

In situ hybridization with cRNA probes showed A2A receptor and Golf mRNAs to be
abundantly expressed in caudate putamen, nucleus accumbens, and olfactory tubercle …

Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or
extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal …

The anti‐Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine
A2A receptor antagonists is believed to result from their ability to postsynaptically control the …

Cortical interneurons born in the subpallium reach the cortex through tangential migration,
whereas pyramidal cells reach their final position by radial migration. Purinergic signaling …

Adenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four
members, named A 1, A 2A, A 2B, and A 3 receptors, found widely distributed in almost all …

This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …

Because an increased glutamate outflow is thought to play a crucial role in triggering
excitotoxic neuronal death, drugs able to regulate glutamate release could be effective for …