It is 30 years since Ebashi and colleagues showed that Ca2+ ions directly affect regulation
of the myosin‐actin interaction in muscle through the action of tropomyosin and troponin on …

The steric model of muscle regulation holds that at low Ca2+ concentration, tropomyosin
strands, running along thin filaments, are constrained by troponin in an inhibitory position …

Contraction of striated muscles is regulated by tropomyosin strands that run continuously
along actin-containing thin filaments. Tropomyosin blocks myosin-binding sites on actin in …

The structural basis of thin filament-linked regulation of muscle contraction is not yet
understood. Here we have used electron microscopy and three-dimensional image …

REGULATION BY TROPONIN-TROPOMYOSIN 537 structural changes cause increased
interaction between actin and myosin, enhanced actomyosin ATPase activity, and …

Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Contraction in all muscles must be precisely regulated and requisite control systems must be
able to adjust to changes in physiological and myopathic stimuli. In this chapter, we outline …

By interacting with the troponin-tropomyosin complex on myofibrillar thin filaments, Ca2+
and myosin govern the regulatory switching processes influencing contractile activity of …

The movement of tropomyosin from actin's outer to its inner domain plays a key role in
sterically regulating muscle contraction. This movement, from a low Ca2+ to a Ca2+-induced …

The author reviewed the research that led to establish the structural basis for the mechanism
of the calcium-regulation of the contraction of striated muscles. The target of calcium ions is …