Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders

A Verkhratsky, V Parpura - Neurobiology of disease, 2016 - Elsevier
Astroglial cells represent a main element in the maintenance of homeostasis and providing
defense to the brain. Consequently, their dysfunction underlies many, if not all, neurological …

Astrogliopathology: a central element of neuropsychiatric diseases?

A Verkhratsky, JJ Rodríguez, L Steardo - The Neuroscientist, 2014 - journals.sagepub.com
Astroglia are the homoeostatic cells of the central nervous system that control a normal
function of synaptically connected neuronal networks and contribute to brain defense …

Astrocytes: a central element in neurological diseases

M Pekny, M Pekna, A Messing, C Steinhäuser… - Acta …, 2016 - Springer
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

Why are astrocytes important?

A Verkhratsky, M Nedergaard, L Hertz - Neurochemical research, 2015 - Springer
Astrocytes, which populate the grey and white mater of the brain and the spinal cord are
highly heterogeneous in their morphology and function. These cells are primarily …

Pathobiology of neurodegeneration: the role for astroglia

A Verkhratsky, R Zorec, JJ Rodriguez… - Opera medica et …, 2016 - cyberleninka.ru
The common denominator of neurodegenerative diseases, which mainly affect humans, is
the progressive death of neural cells resulting in neurological and cognitive deficits …

Astrogliosis: an integral player in the pathogenesis of Alzheimer's disease

LM Osborn, W Kamphuis, WJ Wadman, EM Hol - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …

Astroglia in neurological diseases

A Verkhratsky, JJ Rodríguez, V Parpura - Future neurology, 2013 - Taylor & Francis
Astroglia encompass a subset of versatile glial cells that fulfill a major homeostatic role in the
mammalian brain. Since any brain disease results from failure in brain homeostasis …

Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

General pathophysiology of astroglia

A Verkhratsky, MS Ho, N Vardjan, R Zorec… - Neuroglia in …, 2019 - Springer
Astroglial cells are involved in most if not in all pathologies of the brain. These cells can
change the morpho-functional properties in response to pathology or innate changes of …

Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis

R Kim, KL Healey, MT Sepulveda-Orengo… - Progress in Neuro …, 2018 - Elsevier
Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …