BACKGROUND: IL-22 functions as both a proinflammatory cytokine and an anti-
inflammatory cytokine in various inflammations, depending on the cellular and cytokine …

Rationale: IL-22 has both proinflammatory and antiinflammatory properties. Its role in
allergic lung inflammation has not been explored. Objectives: To investigate the expression …

BACKGROUND: A novel IL-17 family cytokine, IL-25, has been reported to induce IL-4, IL-5,
and IL-13 production from undefined non-T/non-B cells and then induce TH2-type immune …

Allergic inflammation in the airway is generally considered a Th2-type immune response.
However, Th17-type immune responses also play important roles in this process, especially …

IL-22 is a Th17/Th22 cytokine that is increased in asthma. However, recent animal studies
showed controversial findings in the effects of IL-22 in allergic asthma. To determine the role …

Interleukin (IL)-22 is an effector cytokine, which acts primarily on epithelial cells in the skin,
gut, liver and lung. Both pro-and anti-inflammatory properties have been reported for IL-22 …

Abstract T helper 2 (Th2) cells induce allergic inflammation through the production of
cytokines such as interleukin (IL)-4, IL-5 and IL-13. Recently, it has been demonstrated that …

Asthma is the most prevalent allergic disease of the airway, which is characterized by
eosinophilic inflammation, mucus hyperproduction, and airway hyper-responsiveness …

Background Serum IL-22 levels are increased in patients with atopic dermatitis, which
commonly precedes asthma in the atopic march. Epicutaneous sensitization in mice results …

IL‐23‐and IL‐17A‐producing CD4+ T cell (Th17 cell) axis plays a crucial role in the
development of chronic inflammatory diseases. In addition, it has been demonstrated that …